Table 4.
entry | R | yield, (SM)%a | ee, %b |
---|---|---|---|
1 | Phenyl 6a | 91 | 88 |
2 | 4-Chlorophenyl 6h | 71 (10) | 84 |
3 | 4-Methylphenyl 6i | 16 (62) | 63 |
4 | 4-Methoxyphenyl 6j | 84 | 86 |
5 | 3,5-Bistrifluoromethylphenyl 6k | 70 (23) | 90 |
6 | 2-Naphthyl 6l | 95 | 91 |
Isolated yields. Yields in parenthesis are for recovered starting materials.
Chiral HPLC analysis.