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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8335–8343. doi: 10.4049/jimmunol.181.12.8335

Figure 3. Effect of Relative Kinetic Rates of Desensitization and Recycling on Predicted Chemotactic Orientation in Competing Ligand Gradients: Top panel.

Figure 3

Illustration of competing ligand gradients. Lower panels: Equilibrium orientation signals (ΔLR*total) for cells expressing receptors to ligand L1 and L2 with different kinetic rates for desensitization (kdes)(A), internalization (ki)(B) and up-regulation (kup)(C) in competing gradients of L1 and L2 (except when varied as indicated, kdes is fixed at 0.065s−1, ki at 0.0033s−1 and kup at 0.004s−1.). The shaded area indicates ΔLR*total levels below the threshold for orientation, set at ±10.