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T and B cells enter into the gut associated lymphoid tissue (GALT) through interaction between α4β7 and L-selectin on the cell surfaces with intracellular adhesion molecule-1 (ICAM-1) and mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) on the high endothelial venules on the Peyer’s patches. Blockade of α4β7 , L-selectin or MAdCAM-1 reduced cell entry into Peyer’s patches of chow fed mice whereas ICAM-1 blockade had no effect.
