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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Vascul Pharmacol. 2008 Mar 28;48(4-6):202–207. doi: 10.1016/j.vph.2008.03.003

Fig. 4.

Fig. 4

Up4A-induced contraction involves activation of L-type Ca2+ channels and the Rho-kinase pathway. CCEC(s) to Up4A (10−9 to 3×10−5M) were performed in endothelium denuded [E(−)] rat aortic ring in the absence and in the presence of (A) the selective L-type Ca2+ channel blocker nifedipine (10−5M) or (B) the selective Rho-kinase inhibitor Y-27632 (10−7M). The points represent the mean ± S.E.M. of the force displacement in mN, “n” represents the number of animals and * represents P value <0.05 compared to the response obtained in the absence of the inhibitor.