Table 3.

Calculating the effect of trials based on within or between subject comparison of intervention and placebo control treatment

	Intervention					Placebo control					Effect of trial
		SBP		DBP			SBP		DBP		SBP		DBP
Study	n	Mean	SD	Mean	SD	n	Mean	SD	Mean	SD	Effect	SE	Effect	SE
	Within subject comparison of blood pressure
Hata et al. (10)	17	−14.1	12.8	−6.9	10.3	13	−4.4	13.0	−2.2	6.9	−9.7	4.7	−4.7	3.3
Seppo et al. (14)	10	−14.9	9.4	−8.8	6.8	7	−4.1	11.4	−2.0	5.2	−10.8	5.0	−6.9	3.1
Seppo et al. (15)	19	−15.4	8.3	−9.3	4.8	17	−9.4	13.2	−5.5	7.4	−6.0	3.6	−3.8	2.1
Mizushima et al. (16)	23	−5.2	11.3	−2.0	8.0	23	−3.7	10.6	−0.3	8.3	−1.5	3.2	−1.7	2.4
Toumilehto et al. (17)	30	−15.8	13.2	−10.3	6.5	29	−13.5	11.9	−9.8	7.5	−2.3	3.3	−0.5	1.8
Aihara et al.* (8)	20	−5.0	8.9	−6.0	6.7	20	−2.0	8.9	−1.0	8.9	−3.0	2.8	−5.0	2.5
Aihara et al.** (8)	20	−10.0	15.7	−7.5	15.7	20	0.5	11.2	−0.5	8.9	−10.5	4.3	−7.0	4.0
Jauhianinen et al. (18)	53	−5.1	9.4	−1.1	5.6	55	−3.1	11.5	−2.1	6.1	−2.0	2.0	1.0	1.1
Cadée et al. (20)	24	−10.7	7.8	−6.9	5.9	24	−3.6	11.8	−2.7	7.8	−7.1	2.9	−4.2	2.0
	Between subject comparison of blood pressure
Kawasaki et al. (11)	17	137.1	12.0	85.3	8.6	12	142.5	11.5	91.0	8.7	−5.4	4.4	−5.7	3.2
Kawase et al. (12)	10	118.0	9.5	−	−	10	125.0	14.−2	−	−	−7.0	5.4	−	−
Fujita et al. (13)	30	137.5	11.5	86.5	8.2	31	148.5	9.9	92.0	8.4	−11.0	2.7	−5.5	2.1
Mizuno et al.* (9)	12	131.1	5.8	79.8	6.0	12	133.1	5.5	79.2	4.3	−2.0	2.3	0.6	2.1
Mizuno et al.** (9)	21	135.0	10.9	83.9	8.8	20	147.2	10.8	87.3	7.3	−12.2	3.4	−3.4	2.5
Sano et al. (19)	72	132.3	7.3	81.2	4.8	72	136.4	8.0	83.7	5.6	−4.1	1.3	−2.5	0.9
Lee et al. (21)	27	143.7	13.5	90.4	6.5	26	137.0	14.4	87.7	6.6	6.7	3.8	2.7	1.8
Pins et al. (22)	15	126.0	6.2	77.0	5.4	15	133.0	7.4	80.0	5.8	−7.0	2.5	−3.0	2.1

*Data from participants with high-normal blood pressure.

**Data from participants with mild hypertension.