Fig. 1.

(A and B) Tumors implanted into DP^−/− mice have increased tumor growth rates and decreased survival rates. LLCs were injected into WT or DP^−/− mice, and tumor growth and survival were monitored (n = 25 each, *, P < 0.05 vs. WT). (C and D) DP agonism (BW245C) suppressed tumor growth and extended life span. Four days after LLC implantation (quoted as day 0), mice were injected i.p. with saline solution, 50 μg/kg of BW245C, or 3 mg/kg BWA868C twice a day (n = 10, *, P < 0.05 vs. vehicle treatment).