Table 4. Correlation among demographic and phenotypic characteristics of NVAMD and genotyping for LOC387715/ARMS2 (rs10490924).
|
LOC387715/ARMS2 (rs10490924) genotype |
||||
|---|---|---|---|---|
| TT | TG | GG | p | |
| Gender (female/male) |
21/14 |
24/27 |
20/33 |
0.12 |
| Lesion type* (classic/occult) |
11/24 |
23/28 |
19/34 |
0.4 |
| Family History of AMD (yes/no) # |
9/19 |
7/35 |
2/43 |
0.006 |
| Age (mean±SD, in years) |
76.4±8 |
78.9±8.5 |
80.1±7.2 |
0.1 |
| Smoking (yes/no) # |
12/20 |
25/25 |
27/25 |
0.42 |
| Initial VA (mean±SD, logMAR) |
1.06±0.83 |
0.94±0.68 |
1.14±0.79 |
0.44 |
| Lesion size (mean±SD, in µm) |
4081±1347 |
3669±1265 |
3623±1288 |
0.34 |
| Number of PDT sessions |
2.2±2.2 |
2.6±1.9 |
2±1.6 |
0.22 |
| Final VA (mean±SD, logMAR) | 1.5±0.9 | 1.51±0.83 | 1.37±0.93 | 0.67 |
The asterisk indicates that classic lesions included predominantly classic and pure classic lesions. Occult lesions included minimally classic and occult lesions. Analysis according to four lesion types showed similar results. # Reliable information on family history was obtained from 117 out of the 143 participants included in this analysis, and smoking history was obtained from 138 of the 143 study participants.