Table 5. Correlation among demographic and phenotypic characteristics of NVAMD and genotyping for HTRA1 (rs11200638).
|
HTRA1 (rs11200638) genotype |
||||
|---|---|---|---|---|
| AA | GA | GG | p | |
| Gender (female/male) |
14/10 |
25/25 |
29/40 |
0.35 |
| Lesion type* (classic/occult) |
7/17 |
22/28 |
26/43 |
0.46 |
| Family History of AMD (yes/no) # |
5/14 |
9/31 |
5/53 |
0.08 |
| Age (mean ± SD, in years) |
75.6±7 |
79.2±8.5 |
79.5±7.8 |
0.1 |
| Smoking (yes/no) # |
11/12 |
22/26 |
33/34 |
0.93 |
| Initial VA (mean ± SD, logMAR) |
1.1±0.8 |
0.928±0.7 |
1.1±0.8 |
0.38 |
| Lesion size (mean ± SD, in µm) |
4250±1261 |
3696±1290 |
3603±1261 |
0.17 |
| Number of PDT sessions |
2.5±1.9 |
2.4±1.8 |
2.2±1.9 |
0.78 |
| Final VA (mean ± SD, logMAR) | 1.6±0.84 | 1.5±0.84 | 1.36±0.94 | 0.45 |
The asterisk indicates classic lesions included predominantly classic and pure classic lesions. Occult lesions included minimally classic and occult lesions. Analysis according to four lesion types showed similar results. # Reliable information on family history was obtained from 117 out of the 143 participants included in this analysis, and smoking history was obtained from 138 of the 143 study participants.