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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Nat Immunol. 2008 Oct 5;9(11):1236–1243. doi: 10.1038/ni.1660

Figure 3.

Figure 3

Interactions of the P4 p-Ser with the HLA-A2 heavy chain. (a) Left, superposition of the 4 phosphopeptide structures (RTY (blue), KMD (red), PKD2 (grey), RQA_M (light blue)) on the basis of P1 to P4 Cα atoms, with P1 and P4 sidechains shown. Right, orientation of the PKD2 P4 p-Ser side chain (red and pink) relative to P4 sidechains (Asp, Asp, and Asn) of non-phosphorylated HLA-A2-restricted peptides: (PDB codes 1I4F, 3D25, and 1T21 respectively). (b, c) Interactions of the RTY (b) and KMD (c) p-Ser moieties with HLA-A2 α1-α2 helices. Red dashed lines, hydrogen bonds; red sphere, conserved water molecule.