Skip to main content
. Author manuscript; available in PMC: 2009 Sep 10.
Published in final edited form as: Brain Res. 2008 Jul 2;1229:118–124. doi: 10.1016/j.brainres.2008.06.086

Table 1.

Displacement of [3H]epibatidine binding to spinal cord membranes by α-conotoxin MII
Ki (nM) % Total Binding
High affinity Low affinity High affinity Low affinity
Normal 2.7 ± 1.6 83.5 ± 3.2 59 ± 11% 41 ± 11%
SNL 3.2 ± 1.5 67.5 ± 2.1 54 ± 11% 46 ± 11%

Mean Ki values ± S.E.M. of α-CTX MII displacement of 0.8 nM [3H]epibatidine to spinal cord membranes from normal and spinal nerve-ligated (SNL) rats are shown. Ki values were calculated using the previously reported KD = 0.12 nM of epibatidine to α3β2 nAChRs (Wang et al., 1996). The mean percent contribution ± S.E.M. of high and low affinity sites to total α-CTX MII binding in spinal cord membranes from normal and SNL rats is shown.