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. Author manuscript; available in PMC: 2008 Dec 6.
Published in final edited form as: Endocrinology. 2006 Oct 12;148(1):433–440. doi: 10.1210/en.2006-0672

Fig. 1.

Fig. 1

Changes in leptin sensitivity with age and fasting. Male chow-fed Sprague Dawley rats at 8, 12, and 20 wk of age (five to eight rats/group) were treated with a single icv injection of leptin (3 μg), and 24-h food intake was recorded. In addition, a separate group of 20-wk-old rats was fasted for 24 h, injected with leptin after the fast, and 24-h food intake recorded. Leptin treatment significantly suppressed food intake in 8- and 12-wk-old rats (*, P < 0.05) but had no effect on food intake in 20-wk-old rats. However, when 20-wk-old rats were fasted for 24 h, leptin blocked fasting-induced increases in food intake (*, P < 0.05).