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Pharmacological PTP1B inhibition reduces food intake. Twenty-week-old rats bearing icv cannula were treated with higher doses of the PTP1B inhibitor (1 and 3 nmol, icv) than used to enhance sensitivity to exogenous leptin. Intracerebroventricular administration of the PTP1B inhibitor at these higher doses resulted in a dose-dependent inhibition of food intake (P < 0.05) at both 4 and 24 h, consistent with an increase in sensitivity to endogenous leptin.
