Figure 5.

Densitometry and representative immunoblots of hypoxia inducible factor (HIF)-1α, vascular endothelial growth factor (VEGF), prolyl hydroxylases domain (PHD)-2, VHL, phospho- and total Akt, NAD(P)H subunit p47phox, phospho- and total eNOS in HUVEC exposed to TNF-α (1 ng/ml) with and without simvastatin. Simvastatin decreased the expression of VEGF, p-Akt, and p-eNOS, restored 26s proteasome, and had no effect on HIF, VHL, and MMP-9 expression. *p<0.05 vs. normal, †p<0.05 vs. TNF-α