Table 2.

Associations between the ROCK2 haplotypes from LD blocks 1 and 2 and the risk of hypertension. LD blocks were identified with Haploview program and sequences indicate the nucleotides for SNP 1 – 7 in block 1 and SNPs 8 – 17 in block 2 (see Figure 1 and Supplemental Table II for details). ‘LAMP free’ and ‘LAMP rec.’ indicate p-values from unrestricted and recessive models of the LAMP program, respectively. Column “freq.” indicates the frequency of a given haplotype allele in the HYPGENE cohort.

Block 1					Block 2
Haplo	Sequence	freq.	LAMP free	LAMP rec.	Haplo	Sequence	freq.	LAMP free	LAMP rec.
1_1	AAAAATA	0.477	0.7	0.4	2_1	GGGAGAATGG	0.479	0.4	0.3
1_2	AGACTAG	0.216	0.4	0.2	2_2	AGGGAAGAGG	0.162	0.4	0.2
1_3	AGACTTA	0.139	0.012	0.003*	2_3	AGCAGCAAAA	0.128	0.008	0.002*
1_4	GGACTAG	0.064	0.5	0.7	2_4	GGGAAAGAGG	0.064	0.5	0.7
1_5	AGGCTAA	0.056	0.3	0.13	2_5	AGGAGAGAGG	0.057	0.3	0.14
1_6	AGAAATA	0.043	0.5	0.2	2_6	AAGGAAGAGG	0.053	0.9	0.7
					2_7	AGGAGAAAGA	0.05	0.3	0.14

^*False discovery rate: q = 0.02