Table 3.
Associations between the individual ROCK2 SNPs and the risk of hypertension in the HYPGENE subjects. P-values are from additive and recessive logistic regression models that included baseline age, cardiorespiratory fitness, body mass index, sex, and follow-up time as covariates. SNPs 1 – 7 are in LD block 1 and SNPs 8 – 17 in LD block 2.
| # | Name | Position | MAF | Additive | Recessive |
|---|---|---|---|---|---|
| 1 | rs17366517 | 11,271,266 | 0.064 | 0.6794 | 0.6607 |
| 2 | rs6753921 | 11,277,353 | 0.477 | 0.513 | 0.4536 |
| 3 | rs16857265 | 11,281,010 | 0.056 | 0.5329 | 0.2754 |
| 4 | rs9808232 | 11,309,718 | 0.48 | 0.7532 | 0.6852 |
| 5 | rs2056103 | 11,315,354 | 0.475 | 0.6864 | 0.8013 |
| 6 | rs10167277 | 11,316,598 | 0.336 | 0.5371 | 0.2656 |
| 7 | rs10929727 | 11,334,812 | 0.279 | 0.7612 | 0.5152 |
|
| |||||
| 8 | rs4477886 | 11,338,892 | 0.451 | 0.2038 | 0.2805 |
| 9 | rs12479227 | 11,344,951 | 0.053 | 0.9794 | 0.9629 |
| 10 | rs965665 | 11,349,473 | 0.128 | 0.0121 | 0.0031* |
| 11 | rs4669700 | 11,352,136 | 0.216 | 0.2746 | 0.1151 |
| 12 | rs4669702 | 11,354,050 | 0.279 | 0.779 | 0.5273 |
| 13 | rs10178332 | 11,359,615 | 0.131 | 0.0173 | 0.0047* |
| 14 | rs10929728 | 11,362,081 | 0.336 | 0.5471 | 0.2722 |
| 15 | rs2122383 | 11,387,366 | 0.48 | 0.3473 | 0.4236 |
| 16 | rs6755196 | 11,410,923 | 0.131 | 0.0171 | 0.0046* |
| 17 | rs10929732 | 11,434,090 | 0.182 | 0.0483 | 0.0138 |
|
| |||||
| 18 | rs7581184 | 11,440,129 | 0.381 | 0.1001 | 0.0504 |
False discovery rate: q < 0.05