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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Immunol. 2008 Nov 1;181(9):6170–6177. doi: 10.4049/jimmunol.181.9.6170

Figure 7. Activated microglia are protected from NK cell mediated killing.

Figure 7

TLR-ligation on human microglia by LPS protected microglial cells from NK cell-mediated cytotoxicity (Fig. 7A), *p=0.02. In contrast, monocyte-derived macrophages were more susceptible to NK cell mediated cell lysis following LPS stimulation (Fig. 7C), **p=0.004, whereas matured DCs were less susceptible (Fig. 7B), ***p<0.001. In addition, LPS stimulation resulted in an up-regulation of MHC class I surface expression on microglial cells and the protective effect of microglia activation could be reversed by MHC class I blockade, *p=0.002, indicating that this effect was primarily MHC class I-mediated (Fig. 7D). At least 3 experiments for each cell-type are summarized.