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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Eur Urol. 2008 Jan 16;54(4):845–853. doi: 10.1016/j.eururo.2008.01.010

Fig. 3. [en] Knock-down of epidermal growth factor receptor (EGFR) and downstream target genes inhibits growth factor-stimulated branching in 786-0 renal cell carcinoma (RCC) cells.

Fig. 3

From top to bottom, phase contrast photomicrographs (x40 objective) show branching morphogenesis by 786-0 cells transfected with shRNA expression constructs for control (scrambled sequence), EGFR, Akt-1, and MEK-1, stimulated by hepatocyte growth factor (left) or transforming growth factor α (right). Cells were cultured in Matrigel and branching was ranked on a scale from + to ++++, least to most, as indicated at the bottom right of each panel.