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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2008 Sep;7(9):2609–2620. doi: 10.1158/1535-7163.MCT-07-2400

Figure 7.

Figure 7

Summary of the mechanisms by which curcumin inhibits Akt/mTOR signaling and cell survival/proliferation in PC-3 prostate cancer cells. Curcumin activated PP2A and/or unspecified calyculin A-sensitive protein phosphatase activities towards Akt, mTOR, led to the dephosphorylation of Akt/mTOR and their downstream substrates GSK3, FoxO1, p70S6K and 4E-BP1, and finally inhibited the expression of proteins that are essential for cell survival and proliferation. Curcumin also activated MAPKs and AMPK; however these kinases did not play important roles in the curcumin-mediated inhibition of Akt/mTOR signaling and cell proliferation.