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. Author manuscript; available in PMC: 2009 Sep 26.
Published in final edited form as: Biochem Biophys Res Commun. 2008 Jul 23;374(3):405–408. doi: 10.1016/j.bbrc.2008.07.068

Fig. 1. Regulation of HDAC3 cytoplasm/nucleus shuttling by IkBa.

Fig. 1

HDAC3 is enriched in the nucleus after translocation of cytoplasmic HDAC3 into the nucleus. This change leads to inhibition of PPARγ function. The nuclear translocation of HDAC3 is initiated by degradation of IkBa, which is catalyzed by activation of IKK and required for NF-kB activation. NF-kB induces transcription and recovery of IkBa. IkBa then induces nuclear exclusion of HDAC3 and NF-kB through protein-protein association. This event leads to inhibition of NF-kB activity and reduction in HDAC3 protein abundance.