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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Immunol. 2008 Jul 1;181(1):104–108. doi: 10.4049/jimmunol.181.1.104

FIGURE 4.

FIGURE 4

Tc2 cells developed from Stat6−/− mice can effectively migrate into tumor lesions in vivo. Mice bearing established, day 10 s.c. M05 melanomas received i.v. adoptive transfer of 4 × 107 Tc1 or Tc2 cells induced from WT or Stat6−/− mice. TILs were harvested 27 h after the adoptive-transfer of CFSE-labeled cells and stained with PE-conjugated anti-CD8 mAb, and then analyzed by flow cytometry to enumerate the percentage of CD8+CFSE+ populations. Left panel, Representative flow cytometry data from one of three mice per group are shown. Right panel, Mean ± SD of the frequency of CSFE+ cells/1000 TIL for three mice analyzed per cohort. P = 0.003 vs Tc1 WT.