TABLE 1. Patient classification and response to combined treatment.

Patients were classified according to the French-American-British (FAB) classification. The levels of Ser 473 p-Akt and TRAIL-R2 were evaluated by flow cytometry and/or western blot. P: perifosine. T: TRAIL. ED: Effective Dose. A CI < 0.9 was considered synergistic, whereas a CI between 0.9 and 1.1. was considered additive. Results are from 3 different experiments ± sd.

FAB TYPE	Ser 473 p-Akt	TRAIL-R2 UPREG	P+T SYNERGISM AVERAGE CI (ED50+ED75+ED90)
M1 # 1	++	++++	0.23 ± 0.03
M1 # 2	+	++	0.51 ± 0.05
M2 # 1	−	−	0.95 ± 0.10
M2 # 2	+++	++++	0.26 ± 0.04
M2 # 3	+++	++++	0.15 ± 0.02
M2 # 4	−	−	1.08 ± 0.15
M2 # 5	+	+/−	0.84 ± 0.09
M2 # 6	−	−	0.99 ± 0.12
M2 # 7	++	+++	0.39 ± 0.05
M4 # 1	+++	++++	0.18 ± 0.02