Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The interplay of PXR activation and therefore modulation of OATP1A2 expression and function in breast cancer cells is illustrated. Induction of OATP1A2 is expected to result in increased cellular uptake of hydrophilic estrogen metabolites leading to the increased estrogenic effects. This interplay can be modulated by the specific PXR antagonist A-792611.
