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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Nat Genet. 2008 Sep 25;40(12):1461–1465. doi: 10.1038/ng.257

Figure 2.

Figure 2

Association between a sequence variant in PNPLA3 (I148M) and hepatic triglyceride (TG) content. (a) PNPLA3 is a 481 residue protein that contains a patatin-like domain at the N terminus (residues 10-179, UniProt http://pir.uniprot.org/uniprot/) with consensus sequences for a Ser-Asp catalytic dyad (Gly-X-Ser-X-Gly and Asp-X-Gly/Ala)14. The I148M substitution (rs738409) is located between the consensus sequences for the catalytic dyad and is highly conserved. (b) Median hepatic TG content, body mass index (BMI), homeostatic model assessment of insulin resistance (HOMA-IR) and plasma TG levels in the Dallas Heart Study. Values for hepatic fat content were compared using ANOVA. Age, gender, BMI, diabetes status, ethanol use and global ancestry were included as covariates in the model. (c) Median hepatic fat contents and PNPLA3-I148M genotypes in European-Americans, African-Americans and Hispanics in the Dallas Heart Study. Associations between hepatic fat content and PNPLA3-I148M genotypes were tested using ANOVA with age, local ancestry, gender, diabetes status, ethanol intake and BMI as covariates.