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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Nat Neurosci. 2008 Oct 19;11(11):1311–1318. doi: 10.1038/nn.2213

Figure 4.

Figure 4

GIVA-PLA2 reduction improves learning and memory in hAPP mice. a,b, Mice (n=8−15 per genotype; age: 4−6 months) were tested in the cued (a) and hidden (b) platform components of the Morris water maze. In both components, hAPP/PLA2+/+ mice differed from all groups without hAPP (P<0.0001, by repeated-measures ANOVA and Tukey test). In the hidden platform component, hAPP/PLA2+/+ mice learned more poorly than hAPP/PLA2+/− mice (P<0.05) and hAPP/PLA2−/− mice (P<0.01, by repeated-measures ANOVA and Tukey test). c, Representative swim paths of individual mice with indicated genotypes during the last probe trial (platform removed). The blue square indicates the target location during hidden platform training. d, Number of times mice crossed this target location during the last probe trial compared with how many times they crossed corresponding locations in non-target quadrants. Only hAPP/PLA2+/+ mice failed to show a clear target location preference. A two-way ANOVA of target/nontarget ratios revealed significant effects of hAPP (P<0.0001) and PLA2 (P<0.001) and a significant interaction between hAPP and PLA2 genotype (P<0.001). *P<0.05, **P<0.01, ***P<0.001 vs. nontarget locations; ###P<0.001 (Tukey test, mean ± s.e.m.).