Figure 6.
Reduction or removal of GIVA-PLA2 did not affect hAPP or Aβ levels in hAPP mice. a, Hippocampal hAPP protein levels (relative to GADPH) in hAPP mice with different levels of GIVA-PLA2 expression (n=6 per group; age, 4−6 months) were determined by western blotting and densitometric analysis of signals. b–d, Hippocampal and cortical levels of Aβ1-x (b) and Aβ1−42 (c) and Aβ1−42/Aβ1-x ratios (d) in 4−6-month-old hAPP mice with different levels of GIVA-PLA2 expression (n=6−10 per group; age, 4−6 months) were determined by ELISA and expressed as ng per g of tissue.