Table 1.
Expression of proteins and its association with regenerative capabilities in the newt and the axolotl
| Protein | Abbrev. | Newt Dorsal vs Ventral iris (higher) | Newt Dorsal vs Axolotl (higher) | Consistent with Regeneration potential |
|---|---|---|---|---|
| Calcium/calmodulin-dependent protein serine kinase 2α | CaMK2a | D | axolotl | NO |
| Catenin beta 1 | Catenin β1 | V | axolotl | YES |
| Epidermal growth factor receptor | EGFR | D | newt | YES |
| Integrin-linked protein-serine kinase 1 | ILK1 | equal | newt | Maybe |
| Interleukin 1 receptor-associated kinase 4 | IRAK4 | V | equal | Maybe |
| Jun proto-oncogene | jun | V | axolotl | YES |
| Macrophage-stimulating protein receptor α chain | RONa | D | axolotl | NO |
| MAP kinase phosphatase 1 | MKP1 | D | newt | YES |
| Mitogen-activated protein serine kinase p38 α | P38aMAPK | equal | equal | Maybe |
| p21 activated serine kinase 3 | PAK3 | D | newt | YES |
| Protein-serine kinase C α | PKCa | D | newt | YES |
| Suppressor of cytokine signaling 4 | SOCS4 | V | axolotl | YES |
| TNF-related apoptosis-inducing ligand | Trail | equal | newt | Maybe |