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DU145 xenograft growth curves (mm3) (A) and Kaplan-Meier survival curves (B) in Maximum Tolerated Dose study in response to single dose 177Lu-hu3S193 RIT. Mice received saline vehicle (■), 180μg hu3S193 (△), 100μCi 177Lu-hu3S193 (◆), 200μCi 177Lu-hu3S193 (●), 350μCi 177Lu-hu3S193 (□) and 500μCi 177Lu-hu3S193 (◇), (Mean ± SD, n = 6). Statistical significance was assessed at termination of placebo control mice on day 36 (arrow).
