Table 3.
Comparison of MRI brain volumes (least square mean (SD) (cubic centimeters)) and WAIS-R IQ scores in healthy volunteers and schizophrenia patients across rs2344484 genotype groupings
| Healthy Volunteers | Patients | Genotype F (p) | Genotype by Group F (p) | |||
|---|---|---|---|---|---|---|
| MRI brain volumes a | CC/CT (N=145) | TT (N=28) | CC/CT (N=280) | TT (N=39) | ||
|
|
|
|||||
| Cerebral GM | 662.46 (41.59) | 682.37 (26.10) | 663.24 (37.80) | 668.57 (35.79) | 5.79 (.02) | 1.91 (.17) |
| Frontal GM | 250.40 (18.93) | 251.72 (14.55) | 246.58 (20.69) | 248.63 (20.50) | 0.38 (.54) | 0.02 (.89) |
| Temporal GM | 157.04 (10.28) | 160.64 (6.45) | 155.19 (8.61) | 156.40 (7.92) | 3.92 (.05) | 0.95 (.33) |
| Parietal GM | 137.98 (11.32) | 132.38 (8.47) | 127.56 (50.15) | 125.63 (33.51) | 0.43 (.51) | 0.10 (.75) |
| Lateral ventricles | 15.03 (5.94) | 12.43 (5.22) | 16.61 (9.10) | 15.44 (7.96) | 2.98 (.08) | 0.43 (.51) |
|
| ||||||
| Cognitive abilities b | CC/CT (N=136) | TT (N=26) | CC/CT (N=290) | TT (N=39) | ||
|
|
|
|||||
| Verbal IQ | 109.5 (11.1) | 107.9 (8.6) | 89.3 (11.7) | 94.1 (13.8) | 0.90 (.34) | 3.84 (.05) |
| Performance IQ | 110.7 (11.5) | 109.4 (10.0) | 88.7 (13.9) | 92.6 (13.3) | 0.51 (.48) | 2.10 (.15) |
| Full Scale IQ | 111.2 (11.2) | 109.5 (8.4) | 88.0 (12.4) | 92.7 (13.7) | 0.82 (.37) | 3.69 (.05) |
a
Covariates: intracranial volume, age, gender and diagnostic grouping (df=1,491)
b
Covariates: age, gender and diagnostic grouping (df=1,490)
GM: gray matter; CC/CT: C-allele carriers; TT: T-homozygotes