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. 2006 Jan 11;26(2):479–489. doi: 10.1523/JNEUROSCI.3915-05.2006

Figure 5.

Figure 5.

Coexpression of NaChBac in the LNV pacemaker neurons rescues the arrhythmic locomotor activity induced by expression of Kir2.1 inward-rectifier potassium channel. A, B, Representative locomotor actograms of male flies of the indicated genotypes and a summary of the percentages of flies exhibiting arrhythmic (light gray bar), single rhythmic (white bar), and complex rhythmic (black bar) locomotor activity. Expression of Kir2.1 in the LNVs decreases the excitability of the LNV plasma membrane (Nitabach et al., 2002) and induces arrhythmic locomotor activity in >60% of flies when coexpressed with dORKΔ-NC. Coexpression of NaChBac from the NaChBac2 or NaChBac4 transgene insertions significantly suppressed the arrhythmicity induced by Kir2.1 (p < 0.02; χ2). Note that coexpression of Kir2.1 with NaChBac decreases the proportion of flies with complex behavioral rhythms induced by NaChBac expression alone (compare with Fig. 4).