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. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Structure. 2008 Nov 12;16(11):1689–1701. doi: 10.1016/j.str.2008.09.005

a. The relationship between the entropy change (−TΔS) and enthalpy change (ΔH) associated with the binding of NBD-556 analogues to HIV-1_YU2 gp120 is shown. The least-squares regression line is depicted, along with the R² value. b. The relationship is shown between the ability of an NBD-556 analogue to enhance HIV-1 infection of CCR5+ cells and the dissociation constant (K_d) and entropy change (−TΔS) associated with compound-gp120 binding. The symbols associated with the compounds are colored according to the ability of the compound to promote HIV-1 infection of CD4⁻CCR5⁺ cells. The color code is the same as that used in Tables 1 and 2, from red (none/low) to green (high level of enhancement).

a. The relationship between the entropy change (−TΔS) and enthalpy change (ΔH) associated with the binding of NBD-556 analogues to HIV-1_YU2 gp120 is shown. The least-squares regression line is depicted, along with the R² value. b. The relationship is shown between the ability of an NBD-556 analogue to enhance HIV-1 infection of CCR5+ cells and the dissociation constant (K_d) and entropy change (−TΔS) associated with compound-gp120 binding. The symbols associated with the compounds are colored according to the ability of the compound to promote HIV-1 infection of CD4⁻CCR5⁺ cells. The color code is the same as that used in Tables 1 and 2, from red (none/low) to green (high level of enhancement).