Table 2.

Unadjusted and adjusted differences in inflammatory biomarkers in the entire sample (n=356), considering twins as separate individuals.

	Unadjusted
	MPO (pmol/L)	IL-6 (pg/mL)	WBC Count (1000/µL)	CRP (mg/L)	TNFα (pg/mL)	sTNF R-II (pg/mL)	Fibrinogen (mg/dL)
No MDD, mean*	603	1.80	6.08	1.21	1.29	2.00	327
(95% CI)	(556, 654)	(1.65, 1.97)	(5.86, 6.31)	(1.03, 1.42)	(1.20, 1.39)	(1.93, 2.07)	(319, 336)
MDD, mean*	794	2.16	6.70	1.42	1.30	2.10	346
(95% CI)	(701, 899)	(1.85, 2.52)	(6.31, 7.11)	(1.10, 1.83)	(1.16, 1.46)	(1.99, 2.22)	(330, 362)
% Difference	31.7	20.0	10.2	17.4	1.0	5.0	5.8
P	<0.0001	0.04	0.002	0.22	0.93	0.07	0.03
	Adjusted†
	MPO (pmol/L)	IL-6 (pg/mL)	WBC Count (1000/µL)	CRP (mg/L)	TNFα (pg/mL)	sTNF R-II (pg/mL)	Fibrinogen (mg/dL)
No MDD, mean*	606	1.84	6.09	1.25	1.28	2.01	329
(95% CI)	(559, 656)	(1.69, 2.00)	(5.88, 6.30)	(1.07, 1.44)	(1.19, 1.38)	(1.94, 2.08)	(321, 338)
MDD, mean*	791	2.04	6.65	1.35	1.29	2.04	343
(95% CI)	(696, 899)	(1.74, 2.38)	(6.27, 7.06)	(1.05, 1.73)	(1.14, 1.45)	(1.93, 2.16)	(327, 359)
% Difference	30.6	10.6	9.3	8.3	1.0	1.6	4.2
P	0.0001	0.26	0.008	0.56	0.92	0.57	0.12

MPO: myeloperoxidase. IL-6: interleukin-6. WBC: white blood cell. CRP: C-reactive protein. TNFα: tumor-necrosis factor α. sTNF R-II: soluble TNFα receptor II. MDD: major depressive disorder. SE: standard error.

^*Geometric means calculated from means of log-transformed values.

^†Adjusted for marital status, body mass index, habitual physical activity (Baecke score), antidepressant medications, the Framingham risk score, zygosity and previous history of coronary heart disease.