Table 3.
Unadjusted and adjusted differences in inflammatory biomarkers in 67 twin pairs discordant for MDD. Matched co-twin control analysis.
| Unadjusted |
Adjusted |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dizygotic (32 Twin Pairs) |
Dizygotic (32 Twin Pairs) |
|||||||||||||
| MPO (pmol/L) | IL-6 (pg/mL) | WBC Count (1000/µL) | CRP (mg/L) | TNFα (pg/mL) | sTNF R-II (pg/mL) | Fibrinogen (mg/dL) | MPO (pmol/L) | IL-6 (pg/mL) | WBC Count (1000/µL) | CRP (mg/L) | TNFα (pg/mL) | sTNF R-II (pg/mL) | Fibrinogen (mg/dL) | |
| No MDD, mean* (95% CI) |
534 (439, 650) |
1.71 (1.25, 2.33) |
5.57 (5.04, 6.16) |
1.26 (0.53, 1.51) |
1.16 (0.94, 1.42) |
1.80 (1.65, 1.98) |
317 (289, 348) |
518 (427, 628) |
1.80 (1.31, 2.47) |
5.60 (5.08, 6.17) |
1.00 (0.60, 1.65) |
1.14 (0.93, 1.41) |
1.85 (1.68, 2.03) |
323 (294, 354) |
| MDD, mean* (95% CI) |
866 (712, 1053) |
2.67 (1.95, 3.64) |
6.57 (5.95, 7.27) |
1.37 (0.81, 2.30) |
1.13 (0.92, 1.39) |
2.15 (1.96, 2.35) |
365 (333, 400) |
917 (753, 1115) |
2.57 (1.86, 3.54) |
6.58 (5.95, 7.26) |
1.27 (0.76, 2.12) |
1.13 (0.92, 1.39) |
2.10 (1.91, 2.31) |
360 (328, 396) |
| P | 0.0004 | 0.03 | 0.006 | 0.12 | 0.79 | 0.005 | 0.002 | <0.0001 | 0.13 | 0.01 | 0.43 | 0.90 | 0.051 | 0.11 |
|
Monozygotic (35 Twin Pairs) |
Monozygotic (35 Twin Pairs) |
|||||||||||||
| MPO (pmol/L) | IL-6 (pg/mL) | WBC Count (1000/µL) | CRP (mg/L) | TNFα (pg/mL) | sTNF R-II (pg/mL) | Fibrinog en (mg/dL) | MPO (pmol/L) | IL-6 (pg/mL) | WBC Count (1000/µL) | CRP (mg/L) | TNFα (pg/mL) | sTNF R-II (pg/mL) | Fibrinog en(mg/dL) | |
| No MDD, mean* (95% CI) |
623 (499, 780) |
2.04 (1.62, 2.57) |
6.79 (6.17, 7.48) |
1.32 (0.87, 1.99) |
1.49 (1.27, 1.75) |
2.15 (1.96, 2.37) |
320 (301, 341) |
628 (508, 776) |
2.01 (1.65, 2.50) |
6.78 (6.16, 7.46) |
1.24 (0.84, 1.83) |
1.52 (1.29, 1.79) |
2.19 (2.00, 2.41) |
325 (305, 346) |
| MDD, mean* (95% CI) |
732 (586, 916) |
1.72 (1.36, 2.16) |
7.08 (6.42, 7.80) |
1.23 (0.81, 1.85) |
1.49 (1.27, 1.75) |
2.11 (1.92, 2.32) |
327 (306, 349) |
727 (588, 899) |
1.74 (1.40, 2.16) |
7.07 (6.42, 7.80) |
1.30 (0.89, 1.92) |
1.46 (1.24, 1.72) |
2.08 (1.89, 2.28) |
322 (301, 344) |
| P | 0.13 | 0.21 | 0.38 | 0.65 | 0.99 | 0.57 | 0.64 | 0.18 | 0.28 | 0.37 | 0.75 | 0.64 | 0.14 | 0.85 |
| P for MDD-zygosity interaction | 0.046 | 0.01 | 0.09 | 0.11 | 0.84 | 0.005 | 0.10 | 0.02 | 0.02 | 0.14 | 0.10 | 0.57 | 0.009 | 0.10 |
MPO: myeloperoxidase. IL-6: interleukin-6. WBC: white blood cell. CRP: C-reactive protein. TNFα: tumor-necrosis factor α. sTNF R-II: soluble TNFα receptor II. MDD: major depressive disorder. SE: standard error.
*
Geometric means calculated from means of log-transformed values.
†
Adjusted for marital status, body mass index, habitual physical activity (Baecke score), antidepressant medications, the Framingham risk score, and previous history of coronary heart disease.