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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Jun 16;326(3):864–870. doi: 10.1124/jpet.107.135350

Figure 2. IL-1ra reverses the attenuated vascular contractile response to PE after incubation with LPS plus BzATP.

Figure 2

Endothelium-intact aortic rings were incubated with DMEM (Control; n=8), LPS plus BzATP (LPS 100 μg/ml plus BzATP 150 μM; LPS+BzATP; n=7) and LPS plus BzATP plus IL-1ra (LPS 100 μg/ml plus BzATP 150 μM plus IL-1ra 100 ng/ml; LPS+BzATP+IL-1ra; n=7). Data are plotted as the percentage of maximum contractile response to 120 mM KCl. Log EC50 to PE are represented. Data are expressed as mean±SEM of n animals. *P<0.001, LPS+BzATP vs. Control; #P<0.01, LPS+BzATP+IL-1ra vs. LPS+BzATP.