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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Jun 16;326(3):864–870. doi: 10.1124/jpet.107.135350

Figure 3. NOS inhibitors abolish the effects of LPS plus BzATP on PE-induced vascular reactivity.

Figure 3

(A) Endothelium-intact aortic rings were incubated with DMEM (Control; n=8), LPS plus BzATP (LPS 100 μg/ml plus BzATP 150 μM; LPS+BzATP; n=7), l-NAME (l-NAME 100 μM for 40 min in the organ bath after 24 h-incubation with DMEM; n=5), and LPS plus BzATP plus l-NAME (l-NAME 100 μM for 40 min in the organ bath after 24 h-incubation with LPS plus BzATP; LPS+BzATP+l-NAME; n=5). (B) The same curves were represented as (A) in DMEM and LPS plus BzATP.

Endothelium-intact aortic rings were incubated with 1400W (1400W 1 μM for 40 min in the organ bath after 24 h-incubation with DMEM; n=5), and LPS plus BzATP plus 1400W (1400W 1 μM for 40 min in the organ bath after 24 h-incubation with LPS plus BzATP; LPS+BzATP+1400W; n=5). Data are plotted as the percentage of maximum contractile response to 120 mM KCl. Data are expressed as mean±SEM of n animals. *P<0.001, LPS+BzATP vs. LPS+BzATP+NOS inhibitor (l-NAME or 1400W).