Figure 3.

Kaplan–Meier analysis of survival of athymic nude mice bearing intraperitoneal OVCAR-5 human ovarian cancer xenografts. Mice were nu/nu NCr (Animal Production Program, NCI-Frederick). The therapeutic agent was administered at a dose of 1 mg per mouse given intraperitoneally once every other day, for a total of seven doses (n = 10 mice per group) using two different vehicles (lipid vehicle and phosphate-buffered saline [PBS]). The lipid vehicle (n = 20 mice) and PBS (n = 20 mice) were used in separate vehicle control groups following the same dosing schedule. Mice were treated with vehicle alone or with one of the therapeutic agents solubilized in the vehicles. Dotted lines indicate 95% confidence intervals.