Table 2.
Actual weights of MDA-MB-361 tumors grown in the mammary fat pad of athymic nude (nu/nu Ncr) mice*
| Experimental day | ||||||||||||||
| 13 | 19 | 22 | 26 | 29 | 33 | 36 | 39 | 46 | 50 | 53 | 56 | 60 | 63 | |
| Absolute weight, mg | ||||||||||||||
| Mouse 1 | 108 | 117 | 148 | 208 | 196 | 196 | 272 | 343 | 466 | 625 | 756 | 893 | 1008 | 1367 |
| Mouse 2 | 117 | 117 | 117 | 221 | 221 | 361 | 320 | 361 | 225 | 320 | 336 | 425 | 662 | 972 |
| Mouse 3 | 158 | 225 | 253 | 325 | 288 | 385 | 385 | 550 | 696 | 726 | 756 | 1055 | 1172 | 1310 |
| Mouse 4 | 108 | 144 | 225 | 361 | 320 | 338 | 416 | 675 | 972 | 1080 | 1172 | 1328 | 1044 | 1458 |
| Mouse 5 | 75 | 98 | 117 | 196 | 225 | 288 | 325 | 429 | 550 | 575 | 600 | 787 | 1133 | 1268 |
| Mouse 6 | 88 | 106 | 126 | 304 | 288 | 239 | 253 | 288 | 320 | 336 | 352 | 425 | 525 | 689 |
| Mouse 7 | 98 | 117 | 126 | 239 | 225 | 325 | 343 | 405 | 726 | 787 | 893 | 1268 | 1458 | 1504 |
| Mouse 8 | 125 | 125 | 180 | 211 | 245 | 245 | 336 | 336 | 425 | 486 | 564 | 756 | 847 | 992 |
| Mouse 9 | 126 | 135 | 144 | 190 | 190 | 201 | 233 | 281 | 336 | 397 | 397 | 650 | 675 | 772 |
| Mouse 10 | 144 | 144 | 196 | 405 | 405 | 446 | 486 | 564 | 650 | 847 | 926 | 1080 | 998 | 1289 |
| Mouse 11 | 81 | 153 | 153 | 336 | 320 | 272 | 272 | 272 | 325 | 525 | 525 | 550 | 600 | 600 |
| Mouse 12 | 135 | 272 | 272 | 425 | 361 | 474 | 662 | 725 | 625 | 787 | 817 | 1044 | 1172 | 1248 |
| Mouse 13 | 81 | 117 | 117 | 225 | 208 | 208 | 208 | 253 | 384 | 662 | 600 | 600 | 756 | 893 |
| Median | 108 | 125 | 148 | 239 | 425 | 288 | 325 | 361 | 466 | 625 | 600 | 787 | 998 | 1248 |
| Average | 111 | 144 | 167 | 280 | 269 | 306 | 347 | 422 | 515 | 627 | 669 | 835 | 927 | 1105 |
| SD | 26 | 50 | 54 | 83 | 68 | 92 | 122 | 158 | 211 | 220 | 247 | 303 | 275 | 301 |
| SD of the median | 26 | 54 | 57 | 93 | 72 | 94 | 124 | 170 | 217 | 220 | 257 | 307 | 285 | 336 |
| t test vs day-63 values | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 | <.001 | .0323 | .129 | NA |
| Relative weight† | ||||||||||||||
| Mouse 1 | 1.0 | 1.1 | 1.4 | 1.9 | 1.8 | 1.8 | 2.5 | 3.2 | 4.3 | 5.8 | 7.0 | 8.3 | 9.3 | 12.7 |
| Mouse 2 | 1.0 | 1.0 | 1.0 | 1.9 | 1.9 | 3.1 | 2.7 | 3.1 | 1.9 | 2.7 | 2.9 | 3.6 | 5.7 | 8.3 |
| Mouse 3 | 1.0 | 1.4 | 1.6 | 2.1 | 1.8 | 2.4 | 2.4 | 3.5 | 4.4 | 4.6 | 4.8 | 6.7 | 7.4 | 8.3 |
| Mouse 4 | 1.0 | 1.3 | 2.1 | 3.3 | 3.0 | 3.1 | 3.9 | 6.3 | 9.0 | 10.0 | 10.9 | 12.3 | 9.7 | 13.5 |
| Mouse 5 | 1.0 | 1.3 | 1.6 | 2.6 | 3.0 | 3.8 | 4.3 | 5.7 | 7.3 | 7.7 | 8.0 | 10.5 | 15.1 | 16.9 |
| Mouse 6 | 1.0 | 1.2 | 1.4 | 3.5 | 3.3 | 2.7 | 2.9 | 3.3 | 3.6 | 3.8 | 4.0 | 4.8 | 6.0 | 7.8 |
| Mouse 7 | 1.0 | 1.2 | 1.3 | 2.4 | 2.3 | 3.3 | 3.5 | 4.1 | 7.4 | 8.0 | 9.1 | 12.9 | 14.9 | 15.3 |
| Mouse 8 | 1.0 | 1.0 | 1.4 | 1.7 | 2.0 | 2.0 | 2.7 | 2.7 | 3.4 | 3.9 | 4.5 | 6.0 | 6.8 | 7.9 |
| Mouse 9 | 1.0 | 1.1 | 1.1 | 1.5 | 1.5 | 1.6 | 1.8 | 2.2 | 2.7 | 3.2 | 3.2 | 5.2 | 5.4 | 6.1 |
| Mouse 10 | 1.0 | 1.0 | 1.4 | 2.8 | 2.8 | 3.1 | 3.4 | 3.9 | 4.5 | 5.9 | 6.4 | 7.5 | 6.9 | 9.0 |
| Mouse 11 | 1.0 | 1.9 | 1.9 | 4.1 | 4.0 | 3.4 | 3.4 | 3.4 | 4.0 | 6.5 | 6.5 | 6.8 | 7.4 | 7.4 |
| Mouse 12 | 1.0 | 2.0 | 2.0 | 3.1 | 2.7 | 3.5 | 4.9 | 5.4 | 4.6 | 5.8 | 6.1 | 7.7 | 8.7 | 9.2 |
| Mouse 13 | 1.0 | 1.4 | 1.4 | 2.8 | 2.6 | 2.6 | 2.6 | 3.1 | 4.7 | 8.2 | 7.4 | 7.4 | 9.3 | 11.0 |
| Average | 1.0 | 1.3 | 1.5 | 2.6 | 2.5 | 2.8 | 3.2 | 3.8 | 4.8 | 5.8 | 6.2 | 7.7 | 8.7 | 10.3 |
| SD | 0.0 | 0.3 | 0.3 | 0.8 | 0.7 | 0.7 | 0.8 | 1.2 | 2.0 | 2.2 | 2.3 | 2.8 | 3.1 | 3.3 |
*
Tumor weights were calculated as tumor weight (mg) = (tumor length × tumor width2)/2. NA = not applicable.
†
Relative tumor weight = (day T weight/day 13 weight), where day T is each time point beyond the day 13 starting mass.