Table 1.
Effects of various antibiotics on vasodilation induced by periarterial nerve stimulation (PNS) and bolus injection of calcitonin-gene related peptide (CGRP) in perfused mesenteric vascular beds with active tone
| Treatment |
PNS (Hz) |
CGRP (pmol) |
|||
|---|---|---|---|---|---|
| 0.5 | 1 | 2 | 50 | 100 | |
| S2/S1 | S2/S1 | S2/S1 | I2/I1 | I2/I1 | |
| Control | 1.32±0.05 | 1.18±0.08 | 1.15±0.04 | 1.27±0.03 | 1.34±0.07 |
| Erythromycin | |||||
| 1 μM | 1.21±0.02 | 1.15±0.03 | 1.14±0.04 | 1.26±0.02 | 1.21±0.05 |
| 10 μM | 1.22±0.03 | 1.12±0.02 | 1.13±0.04 | 1.20±0.05 | 1.22±0.03 |
| Clarithromycin | |||||
| 1 μM | 1.37±0.09 | 1.11±0.04 | 1.10±0.06 | 1.36±0.07 | 1.23±0.11 |
| 10 μM | 1.26±0.01 | 1.11±0.02 | 1.10±0.06 | 1.17±0.08 | 1.23±0.03 |
| Levofloxacin | |||||
| 1 μM | 1.19±0.02 | 1.22±0.04 | 1.14±0.03 | 1.26±0.05 | 1.18±0.06 |
| 10 μM | 1.22±0.04 | 1.25±0.12 | 1.16±0.04 | 1.12±0.06 | 1.11±0.08 |
| Gatifloxacin | |||||
| 1 μM | 1.26±0.07 | 1.18±0.08 | 1.15±0.05 | 1.12±0.06 | 1.13±0.09 |
| 10 μM | 1.23±0.06 | 1.04±0.07 | 1.07±0.06 | 1.21±0.06 | 1.27±0.09 |
| Telithromycin | |||||
| 10 nM | 1.35±0.08 | 1.21±0.05 | 1.16±0.07 | 1.27±0.13 | 1.31±0.07 |
Values represent the mean±s.e.mean of five rats and the ratio of the first PNS (S1; control)- and second PNS (S2; antibiotics)-induced vasodilation and the ratio of the first CGRP injection (I1; control)- and second CGRP injection (I2; antibiotics)-induced vasodilation.