Table 2.
Effect of telithromycin (TEL) on mean blood pressure (MBP) and heart rate (HR) in anaesthetized rats
| MBP | Pre-treatment (mm Hg) |
After vehicle and TEL injection (% change from the baseline) |
%max | |||||
|---|---|---|---|---|---|---|---|---|
| 1 min | 3 min | 5 min | 10 min | 30 min | 60 min | |||
| Vehicle (n=4) | 115.0±3.7 | 1.4±3.0 | 4.4±4.8 | 6.2±3.3 | 4.3±3.5 | 4.5±2.2 | 7.1±0.5 | 6.2±3.3 |
| TEL 1 μmol kg−1 (n=4) | 115.0±3.6 | −17.2±3.7*,†† | −14.5±3.3*,†† | −11.5±4.1† | −7.8±3.8† | −4.9±2.1† | −5.4±2.2† | −17.2±3.7*,†† |
| TEL 2 μmol kg−1 (n=4) | 114.2±4.1 | −18.7±0.8**,†† | −17.4±2.0**,†† | −15.3±2.5**,†† | −16.7±3.7*,†† | −17.2±6.1†† | −8.5±4.3† | −18.7±0.8**,†† |
| HR | Pre-treatment (b.p.m.) |
After vehicle and TEL injection (% change from the baseline) |
%max | |||||
| |
|
1 min |
3 min |
5 min |
10 min |
30 min |
60 min |
|
| Vehicle (n=4) | 357.8±18.3 | −0.2±1.3 | 0.3±1.4 | 0.1±1.4 | −0.7±2.1 | −0.2±2.1 | −1.2±1.8 | −0.7±2.1 |
| TEL 1 μmol kg−1 (n=4) | 353.5±16.5 | −0.2±1.0 | −0.3±1.2 | −1.2±1.5 | −1.9±1.7 | −1.7±1.6 | −2.3±0.9 | −1.9±1.7 |
| TEL 2 μmol kg−1 (n=4) | 383.7±22.4 | −1.3±0.5 | −0.1±2.2 | −2.1±0.4 | −3.1±2.4 | 1.0±2.3 | −2.9±1.5 | −3.1±2.4 |
Abbreviations: b.p.m., beats per minute; %max, %maximum change.
*P<0.05, **P<0.01 vs baseline; †P<0.05, ††P<0.01 vs vehicle control.
Telithromycin (TEL) was dissolved in the vehicle (1% dimethylsulphoxide) and administered intravenously.