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. 2008 Sep 8;155(6):934–944. doi: 10.1038/bjp.2008.323

Figure 4.

Figure 4

Effects of high concentrations of PTX-2 on the actin cytoskeleton in primary hepatocytes. Confocal imaging of F- and G-actin double-staining of primary rat hepatocytes showing fluorescence (upper row) and transmission (lower row) images. F- and G-actin were labelled with Oregon Green 514 phalloidin and Texas Red DNase I, respectively. Primary hepatocytes incubated with 200 nM PTX-2 (a and d) 500 nM PTX-2 (b and e) and 1000 nM PTX-2 (c and f). Images are representative of three independent experiments. Digital zoom= × 2. Scale bar=50 μm. (g and h) represent dose–response curves of the effect on F- and G-actin of PTX-2 on primary hepatocytes, respectively. Results are expressed as percentage of fluorescence in cells incubated with PTX-2 versus controls (100%). Mean±s.e.mean for n ⩾3 experiments.