Figure 1.

Binding of [³H] silodosin (a, b) and [³H]-prazosin (c, d) to rabbit prostate. Saturation binding curves in intact segments (a, c) and crude membranes (b, d) of rabbit prostate. The ordinate scale represents binding (fmol mg⁻¹ total tissue protein). The specific binding was determined by subtracting the amount bound in the presence of 30 μM phentolamine (non-specific binding) from the total amount bound. Each point represents the mean of duplicate determinations. Each figure is representative of similar results obtained in four separate experiments.