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Semilogarithmic plots of unbound plasma and brain extracellular (EC) fluid 10,11-dihydro-10-hydroxy-carbamazepine (MHD) concentration–time profiles following i.p. administration in a typical control rat, rat with pilocarpine-induced seizures and rat with concomitant efflux transport inhibition through intracerebral verapamil perfusion.
