Figure 3.

Effect of an angiotensin II infusion in vivo on systolic blood pressure (a) and the contraction of endothelium-denuded rat aortic strips induced by endothelin-1 in vitro (b). Strips were obtained from control and diabetic animals in the absence of insulin treatment. Ordinate shows increase in tension (expressed in milligram tension per milligram tissue) measured at the peak of the response. Values are mean±s.e.mean from 8 to 10 experiments. ^*P<0.05 versus controls. ^†P<0.05 versus angiotensin II-untreated diabetic. ^§P<0.05 versus chronic angiotensin II-infused control.