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Effect of endothelin antagonists, BQ123 (a) and BQ788 (b) on endothelin-1-induced contraction of endothelium-intact rat aortic strips in vitro. Endothelin antagonists were used at a concentration of 10−6 M. Ordinate shows increase in tension (expressed in milligram tension per milligram tissue) measured at the peak of the response. Values are mean±s.e.mean from 8 to 10 experiments. *P<0.05 versus controls. †P<0.05 vs IT-diabetic. #P<0.05 versus BQ788-treated control.
