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. 2008 Sep 8;155(7):967–969. doi: 10.1038/bjp.2008.346

Figure 1.

Figure 1

Localization of CGRP receptors at the peripheral end of the trigeminovascular system; CGRP1 receptors are located only at the smooth muscle cells, and at present, there is no evidence of CGRP1 receptors on the sensory axons (autoreceptors). The CGRP antibodies would reduce the availability of CGRP at the receptor sites (through the reduction of available CGRP at the receptor), whereas a CGRP antagonist competes with CGRP at the receptor site. Either way will limit the effect of activation of the trigeminal nerve in migraine attacks (modified from Durham 2004, with permission). CGRP, calcitonin gene-related peptide.