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. 2008 Sep 8;155(7):1093–1103. doi: 10.1038/bjp.2008.334

Table 1.

In vitro characterization of CGRP function blocking antibodies by Biacore (KD), cell-based cAMP blocking and radioligand binding

Name KD rat 25 °C (nM) cAMP blocking assay rat αCGRP KD human 25 °C (nM) Binding assay, IC50 (nM), (in anti-CGRP binding sites) cAMP blocking assay human αCGRP
MuMab 4901a 1.0 Yes 17 125.9 Yes
MuMab 7E9 58 Yes 1.0 10.9 Yes

Abbreviation: CGRP, calcitonin gene-related peptide.

a

muMab 4901 was identified earlier (Wong et al., 1993).