Table 1.
Name | KD rat 25 °C (nM) | cAMP blocking assay rat αCGRP | KD human 25 °C (nM) | Binding assay, IC50 (nM), (in anti-CGRP binding sites) | cAMP blocking assay human αCGRP |
---|---|---|---|---|---|
MuMab 4901a | 1.0 | Yes | 17 | 125.9 | Yes |
MuMab 7E9 | 58 | Yes | 1.0 | 10.9 | Yes |
Abbreviation: CGRP, calcitonin gene-related peptide.
muMab 4901 was identified earlier (Wong et al., 1993).