Table 3.
Anti-CGRP antibody treatment inhibited neurogenic vasodilatation of the middle meningeal artery
| Treatment | Pre-Mab | 5 min | 30 min | 60 min | 90 min | 120 min |
|---|---|---|---|---|---|---|
| Vehicle | 100±18.7 | ND | 108.4±4.9 | 120±13.9 | 103.8±12.5 | 87.4±8.4 |
| BIBN4096BS (300 μg kg−1, i.v.) | 100±14.3 | 47.8±3.9 | 42.9±4.7 | 56.9±7.1 | 76.1±6.7 | 61.6±12.9 |
| muMab 7E9 (10 mg kg−1, i.v.) | 100±11.2 | ND | 82.8±7.1 | 69.6±7 | 53.8±7.2 | 44.3±8.5 |
Abbreviation: CGRP, calcitonin gene-related peptide.
Values are mean±s.e.m. and presented as percentage change from normalized preinjection values.