Figure 2.

Representative original traces of vasorelaxant effects of virodhamine and its vehicle (0.01–1% v/v; ethanol; a) and concentration–response curves of virodhamine and WIN 55,212-2 for their effects on endothelium-intact rings of human pulmonary artery, precontracted with 5-HT (b). (a) Arrows show the moment of application of the particular concentrations of virodhamine or of vehicle. (b) Results are expressed as percentage relaxation of the isometric contraction induced by 5-HT. Means±s.e.mean of 5–37 tissues for each curve. In few cases, s.e.mean is smaller than or equal to the size of symbols.