Figure 4.

Influence of rimonabant (a), SR144528 and capsazepine (b) on the concentration–response curve of virodhamine for its relaxant effect on 5-HT-precontracted endothelium-intact human pulmonary arteries. Results are expressed as percentage relaxation of the isometric contraction induced by 5-HT. Means±s.e.mean of 5–37 tissues for each curve. ^*P<0.05, ^***P<0.001 compared with the respective control (virodhamine alone; as determined by one-way ANOVA followed by Dunnett's post hoc test). In few cases, s.e.mean is smaller than or equal to the size of symbols.