Fig. 4.

Dual modality imaging of the magnetofluorescent contrast agent, CLIO-Cy5.5 [31]. (see also Fig. 2 above). The images shown are: a coronal MR image of the thorax, through the plane of the heart, used for co-alignment with fluorescence tomography images of the heart and thorax. b 2D coronal slice at the level of the heart from a 3D fluorescence tomographic dataset. The fluorescence image has been overlaid onto a white light image of the mouse. The depth resolved 3D fluorescence dataset has been acquired completely non-invasively with a dedicated small animal fluorescence tomography system. Significant fluorescence signal is seen over the heart of an infarcted mouse, further confirming the presence of the MNP in the myocardium. c No significant fluorescence intensity is seen over the heart of a sham operated mouse