Table 1.

Selected superparamagnetic iron oxide nanoparticles (MNP)

	Comment
Short circulating
Ferumoxides (Feridex)	Approved liver imaging agent. Use for stem cell labeling is experimental
Ferrixan (Resovist)	Approved liver imaging agent
Long circulating
Ferumoxtran (Combidex, AMI 227)	Completed phase 3 trials (lymph node imaging). Experience imaging plaque macrophages in humans is highly preliminary
Ferumoxytol (AMI 228)	Studied for iron replacement Rx
Monocrystalline iron oxide (MION-47)	Experimental nanoparticle highly similar to Ferumoxtran. Used extensively in animal models
Monocrystalline iron oxide (MION-48)	Experimental nanoparticle with extremely high transverse relaxivity (R2)
Cross linked iron oxide (CLIO)	Experimental nanoparticle, developed for targeted imaging
Very small superparamagnetic iron oxides (VSOP)	Citrate coated iron oxide nanoparticle